Ipsilateral sequential arm movements after unilateral subthalamic deep‐brain stimulation in patients with Parkinson's disease
Identifieur interne : 000D68 ( Main/Exploration ); précédent : 000D67; suivant : 000D69Ipsilateral sequential arm movements after unilateral subthalamic deep‐brain stimulation in patients with Parkinson's disease
Auteurs : Rocco Agostino [Italie] ; Loredana Dinapoli [Italie] ; Nicola Modugno [Italie] ; Ennio Iezzi [Italie] ; Bruno Gregori [Italie] ; Vincenzo Esposito [Italie] ; Pantaleo Romanelli [Italie] ; Alfredo Berardelli [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2008-09-15.
English descriptors
Abstract
Unilateral STN‐DBS significantly improves the performance of contralateral sequential arm movements. Whether unilateral STN‐DBS also improves ipsilateral sequential movement is unclear. In this study in unmedicated parkinsonian patients, we tested the effect of unilateral STN‐DBS on the performance of ipsilateral sequential movements and compared it with the performance of contralateral sequential movements. Three‐dimensional movements were recorded with the ELITE system and three kinematic variables were considered: total movement time (TMT), total inter‐onset latency (IOL), and spatial accuracy. Unilateral STN‐DBS significantly decreased TMT in the contralateral arm and only tended to do so also in the ipsilateral arm, whereas it significantly decreased IOL and worsened spatial accuracy only on the contralateral side. Before unilateral STN‐DBS a positive correlation was present between the clinical impairment and the TMTs in the contralateral and ipsilateral sides. After unilateral STN‐DBS the UPDRS scores improved in the contralateral and to a lesser extent also in the ipsilateral side. Correlation analysis between clinical and kinematic data showed no differences between the contralateral and ipsilateral sides. Our kinematic findings show that after STN‐DBS parkinsonian patients' performance of a sequential motor task improves significantly on the contralateral but only tended to do so on the ipsilateral side. Ipsilateral changes can be explained by the observation that the output structures of the basal ganglia send large ipsilateral and less dense contralateral projections to the thalamus. © 2008 Movement Disorder Society
Url:
DOI: 10.1002/mds.22203
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Ipsilateral sequential arm movements after unilateral subthalamic deep‐brain stimulation in patients with Parkinson's disease</title><author><name sortKey="Agostino, Rocco" sort="Agostino, Rocco" uniqKey="Agostino R" first="Rocco" last="Agostino">Rocco Agostino</name></author><author><name sortKey="Dinapoli, Loredana" sort="Dinapoli, Loredana" uniqKey="Dinapoli L" first="Loredana" last="Dinapoli">Loredana Dinapoli</name></author><author><name sortKey="Modugno, Nicola" sort="Modugno, Nicola" uniqKey="Modugno N" first="Nicola" last="Modugno">Nicola Modugno</name></author><author><name sortKey="Iezzi, Ennio" sort="Iezzi, Ennio" uniqKey="Iezzi E" first="Ennio" last="Iezzi">Ennio Iezzi</name></author><author><name sortKey="Gregori, Bruno" sort="Gregori, Bruno" uniqKey="Gregori B" first="Bruno" last="Gregori">Bruno Gregori</name></author><author><name sortKey="Esposito, Vincenzo" sort="Esposito, Vincenzo" uniqKey="Esposito V" first="Vincenzo" last="Esposito">Vincenzo Esposito</name></author><author><name sortKey="Romanelli, Pantaleo" sort="Romanelli, Pantaleo" uniqKey="Romanelli P" first="Pantaleo" last="Romanelli">Pantaleo Romanelli</name></author><author><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D52E8E76FF893E88357C0E9E3FB5E862A50FB030</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1002/mds.22203</idno><idno type="url">https://api.istex.fr/document/D52E8E76FF893E88357C0E9E3FB5E862A50FB030/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001667</idno><idno type="wicri:Area/Main/Curation">001432</idno><idno type="wicri:Area/Main/Exploration">000D68</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Ipsilateral sequential arm movements after unilateral subthalamic deep‐brain stimulation in patients with Parkinson's disease</title><author><name sortKey="Agostino, Rocco" sort="Agostino, Rocco" uniqKey="Agostino R" first="Rocco" last="Agostino">Rocco Agostino</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neuromed Institute, “Sapienza,” University of Rome</wicri:regionArea><wicri:noRegion>” University of Rome</wicri:noRegion></affiliation></author><author><name sortKey="Dinapoli, Loredana" sort="Dinapoli, Loredana" uniqKey="Dinapoli L" first="Loredana" last="Dinapoli">Loredana Dinapoli</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neuromed Institute, “Sapienza,” University of Rome</wicri:regionArea><wicri:noRegion>” University of Rome</wicri:noRegion></affiliation></author><author><name sortKey="Modugno, Nicola" sort="Modugno, Nicola" uniqKey="Modugno N" first="Nicola" last="Modugno">Nicola Modugno</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neuromed Institute, “Sapienza,” University of Rome</wicri:regionArea><wicri:noRegion>” University of Rome</wicri:noRegion></affiliation></author><author><name sortKey="Iezzi, Ennio" sort="Iezzi, Ennio" uniqKey="Iezzi E" first="Ennio" last="Iezzi">Ennio Iezzi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neuromed Institute, “Sapienza,” University of Rome</wicri:regionArea><wicri:noRegion>” University of Rome</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, “Sapienza,” University of Rome</wicri:regionArea><wicri:noRegion>” University of Rome</wicri:noRegion></affiliation></author><author><name sortKey="Gregori, Bruno" sort="Gregori, Bruno" uniqKey="Gregori B" first="Bruno" last="Gregori">Bruno Gregori</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, “Sapienza,” University of Rome</wicri:regionArea><wicri:noRegion>” University of Rome</wicri:noRegion></affiliation></author><author><name sortKey="Esposito, Vincenzo" sort="Esposito, Vincenzo" uniqKey="Esposito V" first="Vincenzo" last="Esposito">Vincenzo Esposito</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neuromed Institute, “Sapienza,” University of Rome</wicri:regionArea><wicri:noRegion>” University of Rome</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, “Sapienza,” University of Rome</wicri:regionArea><wicri:noRegion>” University of Rome</wicri:noRegion></affiliation></author><author><name sortKey="Romanelli, Pantaleo" sort="Romanelli, Pantaleo" uniqKey="Romanelli P" first="Pantaleo" last="Romanelli">Pantaleo Romanelli</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neuromed Institute, “Sapienza,” University of Rome</wicri:regionArea><wicri:noRegion>” University of Rome</wicri:noRegion></affiliation></author><author><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neuromed Institute, “Sapienza,” University of Rome</wicri:regionArea><wicri:noRegion>” University of Rome</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, “Sapienza,” University of Rome</wicri:regionArea><wicri:noRegion>” University of Rome</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2008-09-15">2008-09-15</date><biblScope unit="volume">23</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1718">1718</biblScope><biblScope unit="page" to="1724">1724</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">D52E8E76FF893E88357C0E9E3FB5E862A50FB030</idno><idno type="DOI">10.1002/mds.22203</idno><idno type="ArticleID">MDS22203</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Parkinson's disease</term><term>deep brain stimulation</term><term>sequential arm movements</term><term>subthalamic nucleus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Unilateral STN‐DBS significantly improves the performance of contralateral sequential arm movements. Whether unilateral STN‐DBS also improves ipsilateral sequential movement is unclear. In this study in unmedicated parkinsonian patients, we tested the effect of unilateral STN‐DBS on the performance of ipsilateral sequential movements and compared it with the performance of contralateral sequential movements. Three‐dimensional movements were recorded with the ELITE system and three kinematic variables were considered: total movement time (TMT), total inter‐onset latency (IOL), and spatial accuracy. Unilateral STN‐DBS significantly decreased TMT in the contralateral arm and only tended to do so also in the ipsilateral arm, whereas it significantly decreased IOL and worsened spatial accuracy only on the contralateral side. Before unilateral STN‐DBS a positive correlation was present between the clinical impairment and the TMTs in the contralateral and ipsilateral sides. After unilateral STN‐DBS the UPDRS scores improved in the contralateral and to a lesser extent also in the ipsilateral side. Correlation analysis between clinical and kinematic data showed no differences between the contralateral and ipsilateral sides. Our kinematic findings show that after STN‐DBS parkinsonian patients' performance of a sequential motor task improves significantly on the contralateral but only tended to do so on the ipsilateral side. Ipsilateral changes can be explained by the observation that the output structures of the basal ganglia send large ipsilateral and less dense contralateral projections to the thalamus. © 2008 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Agostino, Rocco" sort="Agostino, Rocco" uniqKey="Agostino R" first="Rocco" last="Agostino">Rocco Agostino</name></noRegion><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name><name sortKey="Berardelli, Alfredo" sort="Berardelli, Alfredo" uniqKey="Berardelli A" first="Alfredo" last="Berardelli">Alfredo Berardelli</name><name sortKey="Dinapoli, Loredana" sort="Dinapoli, Loredana" uniqKey="Dinapoli L" first="Loredana" last="Dinapoli">Loredana Dinapoli</name><name sortKey="Esposito, Vincenzo" sort="Esposito, Vincenzo" uniqKey="Esposito V" first="Vincenzo" last="Esposito">Vincenzo Esposito</name><name sortKey="Esposito, Vincenzo" sort="Esposito, Vincenzo" uniqKey="Esposito V" first="Vincenzo" last="Esposito">Vincenzo Esposito</name><name sortKey="Gregori, Bruno" sort="Gregori, Bruno" uniqKey="Gregori B" first="Bruno" last="Gregori">Bruno Gregori</name><name sortKey="Iezzi, Ennio" sort="Iezzi, Ennio" uniqKey="Iezzi E" first="Ennio" last="Iezzi">Ennio Iezzi</name><name sortKey="Iezzi, Ennio" sort="Iezzi, Ennio" uniqKey="Iezzi E" first="Ennio" last="Iezzi">Ennio Iezzi</name><name sortKey="Modugno, Nicola" sort="Modugno, Nicola" uniqKey="Modugno N" first="Nicola" last="Modugno">Nicola Modugno</name><name sortKey="Romanelli, Pantaleo" sort="Romanelli, Pantaleo" uniqKey="Romanelli P" first="Pantaleo" last="Romanelli">Pantaleo Romanelli</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D68 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000D68 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:D52E8E76FF893E88357C0E9E3FB5E862A50FB030
|texte= Ipsilateral sequential arm movements after unilateral subthalamic deep‐brain stimulation in patients with Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |